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I have an Intel Core Duo P8600 and use Virtualbox.

Virtual box some settings about virtualization.

My question is should I enable Intel Virtualization and VT-d?

I found that they were both disabled. Is there any harm in enabling them?

I have nothing called VT-x in my BIOS (which is what I was looking for).

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up vote 8 down vote accepted

If you use Virtualbox, you should enable both. VT-d does direct I/O. And I believe Intel Virtualization is the same as VT-x.

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VT-d allows direct access to the hardware from a virtual machine. Presently VirtualBox does not support this but it won't harm to turn it on. If you install some variety of Linux and use Xen for virtualisation it would support VT-d allowing the direct control of various hardware by a virtual machine such as a 3D graphics card or a sound card.

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Virtualbox will require VTx in order to run 64bit guest OS-ses. It will not run these if VTx is not available. Anand_trex believes are correct. Having run with these settings enable on more than one system I don't believe they harm (either performance or stability). It is, however, harmfull to run two VTx virtual systems at the same time. Running Virtualbox and, for instance, VMWare at the same time will bluescreen you PC, at least on Windows 7. On Windows 8 I have found that the included Hyper-V outruns all other VMs I have tried.

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