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Note: I tried searching first for a duplicate but didn't find any, so apologies if my search failed.

I just accidentally pressed the combination again and lost some work. I like using CTRL+W for individual windows, but I never want to close everything.

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up vote 6 down vote accepted

You can use AutoHotkey to intercept the keyboard shortcut:

SetTitleMatchMode, Regex

#IfWinActive, (- Google Chrome)$
        ;do nothing

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thanks! worked like a charm. Now adding it to my startup programs as well. –  Dez Mar 15 '12 at 17:04
This example did not work for me with AutoHotKey v1.1.09.02. After some tweaking I got this working: #IfWinActive, ahk_class Chrome_WidgetWin_1 ^w::Return #IfWinActive –  Steven Devijver Jan 19 '13 at 21:45
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