I'm having an tough time troubleshooting an application that will not start properly after a move to a new domain controller. The first thing checked was permissions and exceptions in Windows Firewall but they appear correct. The vendor agrees that they are correct. The application works on some of the machines (the most imporant ones luckily) but not others. It also runs when logged in under Safe Mode. There is an AV, but even computers without the AV have this problem.
Knowing this, how can I troubleshoot (my assumption) what on this computer is blocking the application?