I experimented with Winbuilder and after some time I noticed that I cannot resize columns in uTorrent, move bookmarks and bookmark folders in Chrome, then cannot resize columns in Comodo Programs Manager - everywhere !!! Fro example , in uTorrent, columns just froze where I left them last time. But Windows Explorer is functioning properly. Where should I search for this problem ?? I think this is something wrong with registry, but regular registry cleaners do not helps. And I cannot even resize a columns in regedit - this is a real hell !
Start by running the Windows System File Checker utility sfc.exe and see if it finds a corrupt system file.
Can we assume you have used a good anti-malaware tool or two( or three) to assure it is not an infection of some sort?