I find this a bit of a nuisance but I usually use the "volume up/down" key on my Microsoft ergo 4000 to change the volume of my system.
The problem I'm experiencing is every so often, the volume of Winamp goes way down relative to the other apps in the mixer:
So I don't always notice this right away, suddenly I can't hear Brandy warbling. And that makes me sad. Or mad. Or both. But it's a nuisance - is there a special key combination I need to avoid pressing to stop the mixer from imbalancing? Is there a way to disable this "app specific" mixer, because it is completely useless to me.