I get this bug VERY often.
When opening a solution or after a compile pressing the "Debug" hotkey (F5, i set it to C# keyboard mapping) the IDE will not run the app. Ctrl F5 will run it (runs outside of the IDE w/o a debugger) but F5 wont work itself. If i click the button in the IDE to run it still won't run. I have to let it sit for 40+ seconds before F5 will work. When the app closes I cant always start it in debug mode again. Something is weird. When i first install visual studios 11beta it didnt do this (I have updated visual studios with one of their patches tho).
Does anyone know a fix? I'm running on windows-7