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Occasionally, I have an issue where the mouse hotspot will be about 10-20px off. For example, mouseovers and clicks will be detected to one side of where the cursor appears to be pointing.

I have a multi-monitor system consisting of an eyefinity-6 array and three additional monitors. This only occurs on one screen. Not a specific one, but one at a time. It comes and goes. I've gone through several video cards, all ATI, and this has happened on and off throughout the years.

A cold boot corrects the problem.

What could cause this?

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I would be interested to know if it happens on an NVIDIA card. – hydroparadise May 8 '12 at 16:47
up vote 1 down vote accepted

The unfortunate solution is to reboot or restart the display adapter.

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