By default, you should disable all autoplay features on your computer. Autoplay is a huge security risk when enabled, since programs are launched without your explicit action/permission.
Assuming you simply want a shortcut that plays the DVD video of whatever is in drive
E:, you should be able to create a shortcut on your desktop to the media player, and pass it the path to the DVD drive as the only argument. For example, using VLC, create a shortcut with the following as the target:
"C:\Program Files (x86)\VideoLAN\VLC\vlc.exe" "E:\"
Clicking the shortcut should start playing whatever DVD is in drive
E. Depending on your media player, you may have to modify the shortcut arguments, but the above should work for all media players which support drag-and-drop onto the executable.