I've always thought my font looked too fat and blurry in Sublime Text 2, almost as if it's constantly bold, so I decided to open Gedit and Sublime Text side by side and compare. Indeed, all fonts look much sharper and clearer in Gedit. I confirmed that the system wide settings (Appearance->Fonts->Rendering) has no effect in Sublime Text 2 by changing them and watching Gedit following the changes, and Sublime Text 2 staying exactly the same.
Why isn't Sublime Text 2 affected by system wide font rendering settings?