I have a funny problem. Normally when I have the screen rotated 180 on the laptop as I'm writing on it everything works just fine. But if I connect an external monitor that is oriented "normal", with the laptop at 180 rotated the pen and finger touch response is completely reversed. I go right, it goes left... and it matches dead center in the screen. It works if I rotate the external screen by 180, on the head. Not very practical.
To sum it up: When connected to an external monitor with laptop screen rotated 180 degrees and the external at normal the pen and touch motions are reversed. I couldn't calibrate the pen to work this way either. Because I would click the opposite diagonal corner.