Cheat Engine is an open source tool designed to help you with modifying single player games running under window so you can make them harder or easier depending on your preference(e.g: Find that 100hp is too easy, try playing a game with a max of 1 HP), but also contains other usefull tools to help debugging games and even normal applications.
It comes with a memory scanner to quickly scan for variables used within a game and allow you to change them, but it also comes with a debugger, disassembler, assembler, speedhack, trainer maker, direct 3D manipulation tools, system inspection tools and more.
Source: About Cheat Engine
Cheat Engine was written with specifically Microsoft Windows libraries, so I can't cross-compile it for Mac or Linux.
What Mac OS X or Linux alternatives are there for Cheat Engine?