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I have been trying to download files on Google Chrome recently and it completes downloading the file, but when I try to run it, it gives me this error:

Windows cannot find 'D:\Downloads\minecraft.jar'. Make sure you typed the name correctly and then try again.

It's not only this file and I have also tried the same on Firefox.

I rebooted the computer but the problem persists. Also, the computer wouldn't turn on after being rebooted until I unplugged my USBs. Any help would be greatly appreciated.

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Where are your downloads set to go to? D:\Downloads? You can check by following these instructions‌​. – Kasius Sep 26 '12 at 20:22
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What happens if you choose 'show in folder'? Can you see the file there? If not, can you see it while it is being downloaded (i.e. does it then disappear)? – Martin Wilson Sep 26 '12 at 20:33
    
While googling around, I found this guy saying that it was because of a virus. As far as I got it, the virus was infecting new download, so the antivirus was deleting those files. Try to download something with your AV off, and if it works, plan a full AV scan at reboot. – m4573r Sep 26 '12 at 21:41
    
When I choose 'show in folder', no window comes up. – skateboard34 Sep 26 '12 at 23:52

It has been happening to a LOT of people. Someone even put a list of all the places discussing this to make it easier for people to keep track of when someone actually finds a solution. What is known as "the AVG work around" has worked for some but NOT all people. Also some report this only happening with Chrome browsers while a few others have experienced this with other browsers as well. A couple people accuse the latest Windows updates. Cannot verify at this time how people not using Windows are affected.

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