I know that .Net programs will fail to run if the CLR IS DELETED, but Im just curious about windows itself.
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One wouldn't think that Windows would allow critical parts of itself to be placed in the Installed Programs (Add/Remove) list with uninstallation just a click away. I've never heard that .Net Framework is in any way essential. If you really want to be rid of it, I would advise using the regular uninstall method, rather than just deleting the files and leaving an unholy mess of dangling registry references behind.