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I subscribe to mailing lists, and have rules that route them to folders under my inbox.

Will setting up an out-of-office auto-reply send a message to the public list for every incoming message?

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If you want to know for sure, just try it using a separate accound and public list. – Tom Wijsman Sep 30 '12 at 23:02

Yes, it will. Automatic Replies (Out of Office) are sent to the sender of the incoming email and regardless the source of incoming email.

To avoid it, you need to setup a rule to exclude those addresses.

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To avoid haveing an out of office response sent to outside of your organization senders, when setting the OOO Open the tab tilted "Outside My Oranization", make sure the "Auto-reply to people outside my organization is not checked. An additional option on this tab is to have responses sent to "My contacts only"

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