Note: I am aware of similar questions. The one's I seen here are for Windows, OSX, and Linux (which I do not need). I also can use Mountain Lion, which the other questions did not mention.
I was going to use NTFS, but OSX Mountain Lion can only read that filesystem and not write to it for some reason. I want to use something native between OSX and Windows, as I don't want to risk losing the data over filesystem incompatibilities.
I have USB 3.0 and want something that will allow files greater than 4GB. I do not mind installing a small set of drivers on the Windows machine(s), but I would strongly prefer to leave the Mac machine untouched.