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I have a excel file I've put on a file server. When required i access it via a dll, fill it with some data in background only (through ExecuteExcel functionality).

It used to work before. Recently I changed 2003 office to 2010 office version. After that it started throwing below error.

System.Runtime.InteropServices.COMException (0x80070BBC): Office has detected a problem with this file. To help protect your computer this file cannot be opened.

Even now also it works sometimes, and sometime throws above error.

What is the problem here?

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Can you please edit this question and give us more detail? What version of Excel, what type of server, how is the file being executed, etc? – CharlieRB Oct 26 '12 at 12:01
@CharlieRB:I have editted my answer.Please ask me if yu don`t understand. – niveiwish Oct 26 '12 at 12:09

Office 2010 file validation requires files or file locations to be trusted. Here is a knowledge base article about it - Error message in Microsoft Office 2010: "Office has detected a problem with this file".

Try adding the location of the file to trusted locations in File > Options > Trust Center > Trust Center Settings > Trusted Locations

Add, remove, or modify a trusted location for your files.

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Charlie:I went through this article.I have given a trusted location to where i copy files.But still same problem. – niveiwish Oct 26 '12 at 12:56
Although I wasn't accessing the files in the same manner as you, I had the same problem when we upgraded to 2010 and this is how we fixed it. Have you installed all Windows & Office updates and restarted your computer? Do you still get the error with a local (on your hard drive, not on the network) copy of the file. – CharlieRB Oct 26 '12 at 13:52
:Yeah i restarted system.Updated office and windows.I got to know that its failing to get cellnames of hidden columns.I dont know why it`s failing.You have any suggestions???? – niveiwish Oct 29 '12 at 9:51

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