If you're not a mouse lover, you will find these two keyboard shortcuts helpful:
CTRL + SHIFT + \ (backslash) toggles allowance status for the current top-level site - temporarily by default, to make it permanent set the about:config noscript.toggle.temp preference to false.
CTRL + SHIFT + N opens the NoScript status bar menu, which lets you perform every NoScript related operation using the cursor keys.
Both these shortcuts can be changed using the about:config noscript.key.* preferences.