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I am configuring a workstation for heavy and memory expensive numerical computing. I have the budget to put 128G of RAM. I have the choice between eight 16Gb modules or 16 8Gb modules. Both configs are about the same price. Is there a reason why I should prefer one over the other. I am using two CPU's Xeon E5-2643 3.30Ghz 4cores

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I assume the motherboard as 16 memory module slots. If you only use 8 of those 16 then you are left with 8 additional modules you can use in the future. –  Ramhound Dec 6 '12 at 14:32
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Might help to state the motherboard type. I remember that some of the SF folk mentioned that the order the ram is in is important, as would the maximum amount of ram on it –  Journeyman Geek Dec 6 '12 at 14:42
    
is that all there is to it ? There are no potential performance issues etc. with using the larger 16G modules ? Reliability ? Addressability ? –  Mathias Vanwolleghem Dec 6 '12 at 14:44
    
@MathiasVanwolleghem - There is pleanty of research on the subject. You asked for a reason so I provided one to you. –  Ramhound Dec 6 '12 at 18:23
    
As @Journeyman Geek noted, we could use more info on the board. You should be able to find a suggested RAM configuration for the motherboard to assure best performance and best future upgradability. –  Dave M Dec 6 '12 at 18:24

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