I want to remove the standard "Find" from +F and bind the key combination to my own program.
Is there a way to perform this task without any hook applications, for example, changes made through registry?
Since you mention "hook applications", guess you know about AutoHotKey and the like. You can disable all built-in Windows hotkeys except +L and +U by making the following change to the registry (should work in XP+):
To make +F launch a custom app would indeed require a keyboard hook; I don't believe you can do without one. The Scancode Map REG_BINARY value under