Not necessarily the easiest, but TikZ/pgf is quite powerful and once you learn the syntax, it's really not that bad, especially if you only care about the output and not placement in a LaTeX document.
HERE is the page from their user-submitted example site showing trees, for example this one (LINK):

While the code might appear annoying, it's quite systematic and intuitive (again, once you learn the syntax). The advanced typesetting you get from LaTeX might also be desirable. Again, not for everyone, but I at least wanted to point it out.
The fact that the examples page is quite prolific is awesome in that you can look at something similar to what you want and just tweak it for yourself.
Ditaa might also be of interest, but the drawings are all done in ASCII and thus again might not be appealing to everyone. Still pretty neat. From the linked page, their example looks like this:
+--------+ +-------+ +-------+
| | --+ ditaa +--> | |
| Text | +-------+ |diagram|
|Document| |!magic!| | |
| {d}| | | | |
+---+----+ +-------+ +-------+
: ^
| Lots of work |
+-------------------------+
Which, upon export becomes:
