This is a Windows 7 64-bit install. Towards the end of the day, all of the sudden, their computer will grind to a halt. It stops responding for a few seconds while performing any action.
I ran ProcMon while the problem was occurring, but I'm not sure what the problem is. The logs indicate that Explorer.exe is reading from the registry thousands of times per second, but there doesn't appear to be any reason for it to be doing so.
The slowdown happens randomly, in many different programs the users uses, but always around the end of the day. It goes on for a long period of time, but can be cured immediately by a reboot.
I have trace logs available at http://sdrv.ms/13TAX56