I have tried all ports on my Windows Vista HE laptop, I have tried different USB mice as well. I still have a problem that when the mouse moves too fast or when the cord dangles down by putting the computer on my lap and the mouse on a side-table, it will freeze.
I occasionally even get a message that the USB device is not recognized. The fix is to pull the USB out of the port, wait for 5 sec., and plug back in until it freezes again. Initially this only gave me trouble with the mouse, but I have also noticed it with a USB connection to an mp3 player.
On occasion, I can let the computer go to the screen saver and the mouse works fine, but there is no pattern to any of this. The best pattern I can find is that I have to have my laptop sitting on a desk at all times with little movement to it (remember, ports don't matter, nor the mouse).
The issue is getting worse and before I take it to a PC specialist, I would like your opinion.