Unfortunately I am stuck with a monitor at work which only has a VGA connection, no DVI input is available. What's the best way of calibrating the monitor so I can get the best sharpness and color?
Ideally, you would use a hardware calibrator like the an Xrite Eye One Display 2 (there are less expensive ones available) to accurately calibrate your monitor's color. Barring that, there are some software-based calibration utilities available as well. I'd give Calibrize a try (it is free!).