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I have a desktop that runs Windows XP. All of a sudden the mouse and keyboard stopped responding(they are both microsoft wireless).

The first thing I tried was to change the USB port of the transmitter but they still don't work. The next move was to change keyboard and mouse. I tried a PS2 keyboard I had spare, but it didn't seem to be working. I also used another wireless mouse in various usb ports, but again no signal!

All these mice and keyboards work perfect in other desktop/laptops.

I have to mention that keyboard is working like a charm on BIOS.

The last step was to use a live USB ubuntu 12.04 stick. In loads fine and both keyboard and mouse are working perfectly.

What can I do to fix the problem and use the keyboard and mouse in windows?

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So you are saying a non-wireless USB keyboard and mouse did not function on this system? – Ramhound Jun 5 '13 at 17:39
Try to reset the BIOS to factory defaults. – quark8 Jun 5 '13 at 17:41
@Ramhound: Thank you very much for your comment! A PS2 keyboard isn't working on windows. But everything is working on BIOS and ubuntu 12.04. – Thanos Jun 5 '13 at 17:42
Get rid of XP.. – BigHomie Jun 5 '13 at 17:46
I do not understand why the question received negative votes. – quark8 Jun 5 '13 at 17:48

Statistics as in SAS or SPSS? Those are available for Windows 7, XP is going to be end of life in less than a year, I know this isn't the answer you're looking for, but you're barking up the wrong tree. There's little point in resetting the BIOS when it works on the live USB, especially if the mouse and keyboard work in the BIOS. The problem is the OS, you can try reloading the drivers like the first answer said, but since PS2 devices have the same problem you'll probably wind up spending several hours tracking the problem down, which could be spent backing up your girlfriend's data and doing a clean install of Windows 7.

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I turned of the system, plugged in the PS2 mouse and logged in windows.

The OS automatically installed the software for the wireless keyboard and mouse. Now everything is working like a charm!

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