Everytime I reboot, i need to to go the Control Panel / Mouse Properties / Pointer Options and cranck up the pointer speed. Is there a way to persist this setting?
I've had the same problem with Vista and Windows 7.
You could throw a batch file in your startup folder:
reg add "HKCU\Control Panel\Mouse" /v MouseSensitivity /t REG_SZ /d 20 /f
Just change the sensitivity as desired. 1 (lowest) - 20 (highest). Save as