When I attempt to run phpMyAdmin (both 3.5.5 and 22.214.171.124) or Drupal (7.22) in chrooted Apache (2.2.3), I get the WSOD (White Screen Of Death; a.k.a. a blank page). I have tried with both mod_chroot (0.5, apache 2.2.3) and ModSecurity. The HTTP response codes are 500, but there are no errors in any of the logs.
I have verified that sessions and MySQL work when mod_chroot is enabled. I have also verified that both phpMyAdmin and Drupal work when mod_chroot is disabled.