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On a Windows Vista home are two user-acounts one with administrator-proîviledge and annother one as a user. Now it happens that the account with admin-rights doesn't work anymore: Profile not loading...

What can be done to bring this thing-a-magic to fly again?

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Have you tried restarting? – Daniel A. White Oct 31 '09 at 15:22

This article might help:

How to Fix the Error "The User Profile Service failed the logon. User profile cannot be loaded" :

The jury is still out on the exact cause, but so far :

  • This issue may occur if the user profile was manually deleted by using the command prompt or Windows Explorer by a user or by some program. A profile that is manually deleted does not remove the security identifier (SID) from the user profile list in the registry. Since the SID is still present, Vista will still try to load the profile by using the ProfileImagePath that points to a nonexistent path. Therefore, the profile cannot be loaded.
  • This can also be a issue with the user profile entering into a backup state.
  • Manually renamed the C:\Users(User Name) folder.

The article then lists several methods of fixing the problem.

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Quick comment - have used this multiple times on windows XP systems to fix filesystem errors/viruses/corruption from faulting hard drives. Unsure if there's similar for Vista and not got time to check! :) – HaydnWVN Nov 8 '11 at 16:23

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