In my experience yes. I once had an internal hard drive that had a similar amount of files. It was rarely defragmented, so it had a lot more reading work to do. The hard drive barely ever seemed to come to rest and ultimately it failed in a peculiar way: While booting Windows it would blue screen due to reading errors. The amount of small files Windows had to read during start up caused the drive to give out. I hooked it up to another computer and was able to access it normally, but SMART indicated that it wasn't alright.
So excessive wear can kill your hard drive and it can occur if your drive has a lot of reading and writing to do. I assume you're using NTFS. This is a journaling file system that logs countless variables regarding each and every file. This of course increases the workload Windows puts on the drive and this workload increases the more files you have and use.
However, you weren't specific in how the other hard drives failed. There could have been a myriad of reasons. I had relatively new drives fail on me that barely ever had been used. So the advice given by the other users still apply. You can use tools like CrystalDiskMark to check your hard drive's temperature and SMART status. Make sure the hard drive is placed on a stable surface that isn't prone to vibrations and shocks, so preferably don't place it on the table you're working on. I also regularly power down my external drive if I know I won't have to access it for a longer period of time. No point in keeping it spinning and create heat for nothing.
Lastly, it should be mentioned that the build quality of hard drives seems to have been lower and lower with every generation. Basically all my newer drives I purchased in the last 3 years are dead by now, while all my older drives that have seen a lot more work still function. This is a well known problem and it is due to the fact that manufacturers try to offer huge drives for cheap prices. If money is no issue, you might want to spend an extra dime. Look for drives with long warranty times as those indicate trust of the manufacturer in its own drive. Stay away from those that only have a year or less of warranty. The safest bet would be to use SSDs though, as they at least don't have any mechanical parts that can fail and those are the main reasons why hard disks give out.