In git version, new feature
layout was introduced.
layout new [title]
Create a new layout. The screen will change to one whole region and be switched to the blank window. From here, you build the regions and the windows they show as you desire. The new layout will be numbered with the smallest available integer, starting with zero. You can optionally give a title to your new layout. Otherwise, it will have a default title of "layout". You can always change the title later by using the command layout title.
even if you detached screen session, layout has remember how region was split.
for example, screen start with follow configuration.
And reattach this session, you will able to come back into (last selected) layout which has 3 splitted region.