I have a Lacie D2 Quadra that I have been using through firewire 800. Mac pros at school have an eSata hookup, but my HD will not show up when I try to use it this way. I have assumed the drive is not hotswappable and turned the comp on after plugging in the drive. Am I missing something about eSata here?
Assuming your eSata drive is, like mine, connected ultimately to the 'spare' eSata port on earlier MacPros, its not hot-swappable so won't be picked up except after reboot. But it should 'just work' - no config or enabling is usually required. Have you tried it with a more than one of your school MacPros?
For what its worth, you are not alone and, like this guy, you might even get some help from Lacie with this.