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I keep getting an error saying:

This is no disk in the drive. Please instead a disk into drive I:

Then I get an error saying;

The iPod cannot be ejected because it contains file that are in use by another application

How is this possible, why would any other application be looking at my iTunes files?

any suggestions?

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If you use Windows on your computer, is there a box popping up asking about how to handle the drive plugged in? – Tom Nov 23 '09 at 16:22
up vote 2 down vote accepted

If this is Windows: Antivirus scaning your iPod? Several other fixes here: "Ipod cannot be ejected" - Page 2 - iLounge Forums.

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I had this same problem. All I did was a reset of my iPod, and it really seemed to cure the issue. I hope that will work for you too!

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