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iTunes is always popping up on my HTPC Mac Mini and I don't use it. It is running Snow Leopard if that makes any difference to the solution

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Slow Leopard? Sounds like you have an opinion about Apple's new OS. – ephilip Dec 28 '09 at 20:29
lol, that's a funny typo – Paul Lockwood Dec 28 '09 at 23:47
up vote 4 down vote accepted

Of course, check out the Apple support article, Removing iTunes for Mac OS X . (note: no longer links to the expected article, appears to have been removed.)

UPDATE: Here's an article for removing iTunes in Lion.

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Thanks, Google drew a blank for me – Paul Lockwood Dec 28 '09 at 23:49
Whilst this may theoretically answer the question, it would be preferable to include the essential parts of the answer here, and provide the link for reference. – Canadian Luke Oct 17 '12 at 23:32

If you want to just disable it, run sudo chmod -x /Applications/
It won't work anymore.

If you want it back, just sudo chmod +x /Applications/

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This is a neat, non-destructive solution. – spume Nov 17 '14 at 13:47
thanks for this - iTunes is far too invasive, this is just what I needed – lfender6445 Mar 17 '15 at 19:35

iTunes, doesn't "just pop" up. It has to be started.

1) Check in the Dock, right click on the iTunes icon, is "Open at Login" checked? 2) Do you have an iPod, iPod Touch, or iPhone? If so, when the device is connected, go into iTunes. Click on it in the sources list, and uncheck the "automatically sync when connected".

Those are the options that I can think of off the top of my head... But iTunes should not be starting without a reason.

Oh, it'll also start up if you have it set to automatically download track information for CDs / DVDs from the internet.... When you insert the discs...

But I think that's it.

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Could have been DVDs left in the drive. Also it started up when charging an iPod. I sync the iPod with a different machine but we tend to charge things off the htpc because it is always on – Paul Lockwood Dec 28 '09 at 23:51
If you are charging an iPod/iPhone/etc, just turn off the "Automatically sync when connected" in iTunes for that particular iPod... That would prevent it from starting up when you plug in the iPhone/iPod. – Benjamin Schollnick Dec 29 '09 at 3:17
uninstalling worked even better :) – Paul Lockwood Dec 30 '09 at 1:46
I know this is old... But there's also the iTunes helper app. Go to System Preferences => Users and Groups, look in Login Items, see if you have iTunes Helper there. Remove it if it is. – Rich Homolka Jul 1 '14 at 14:19
I've known iTunes to fire up when the play/pause button on a keyboard is used, and when an Apple IR remote is used. – spume Nov 17 '14 at 13:42

If this is happening when you insert a Music CD or DVD then it's easy...

System Preferences > CDs & DVDs

In the drop down list labelled "When you insert a Music CD:" (or "...DVD:") select "ignore".

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How I disabled iTunes. Highlight the non running iTunes app and click command i and under sharing and permission give yourself access to read and write. You may need to give yourself root access first. Compress iTunes incase you want to retrieve it. Move iTunes to the trash and click delete.You may need to open Activity monitor and quit the iTunes Helper App first.

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The terminal command doesn't work for me in OSX 10.8.5 anymore so I found a workaround.

  1. Quit iTunes helper using Activity Monitor.
  2. Give yourself permission to read and write using iTunes get info
  3. Use dropDMG and make a disc image of iTunes in case you need iTunes for some reason
  4. Find iTunes, right click "show package content", click Macos, send iTunes and helper 1&2 to the trash and delete
  5. Never software update iTunes

Hope this helps

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Can you specify which terminal command you are referring to? – lzam Sep 22 '14 at 2:19

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