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My registry entry HKEY_CURRENT_USER\Software\Microsoft\Internet Explorer\Main is being locked up by malicious software. My home page is changed and I can't change it back because of the entry's permission being set to "READ ONLY".

How can I remove the lock and change the key?

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I solved by myself! Right Click on the entry and select "Permissions"->"Advanced"->"Owner". There it is "SYSTEM". Change it to "Administrators". Then I can change now. Damn that malicious software!!! – Sefler Jan 21 '10 at 12:31
consider writing this as an answer yourself, instead of a comment, as this solved your problem. – Gnoupi Jan 21 '10 at 13:37
up vote 4 down vote accepted

I solved it:

  1. Right-click on the entry and select "Permissions"→"Advanced"→"Owner".
  2. Change "SYSTEM" to "Administrator"

Now the entry can be modified.

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It seems you are actually "infected" by some malware, but don't worry it doesn't seem to be important.

You should use HiJackThis to determine which malware is on your computer (install, launch, copy the result and paste it in the main page form to examine it) or use some spyware removal tool (Ad-Aware/Spybot), an antivirus AND CCleaner, several times to be sure your computer is clean. You can then check it again with HiJackThis.

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