The short answer is "You can't".
The basic email protocol does not have any mechanism which requires acknowledgement of receipt built in to it, and once the email has left you, its no longer in your control, and (rightly imho), you do not get to dictate what can be done with it.
There are a few things which can be done which can confirm if an email has been read - however there is no requirement that the recipient do these things, so its a matter of "if they do these things you can confirm they have read it, but if they don't confirm, it does not mean they have not read it". These also require preparation BEFORE the email is sent, so won't help you unless you send another email (or did them before hand).
The first thing you can do is specify a "read receipt" request. When an email is opened it can send a notification to the sender confirming it has been read. Most applications will, however, prompt the recipient before sending t he confirmation. This mechanism uses the browser.
The alternative mechanism requires crafting an email with images (often, but not always a 1x1 clear pixel), with a unique name hosted on a web server. If and when the mail client opens the image, the web server can track that the image has been sent. This mechanism is often used by mailing lists - and, of-course, mail clients can be configured not to open off-site images or 1x1 images etc.