Here are the descriptions of these four updates :
December 2015, cumulative time zone update for Windows operating systems
The Windows 10 Universal CRT is a Windows operating system component that enables CRT functionality on the Windows operating system. This update allows Windows desktop applications that depend on the Windows 10 Universal CRT release to run on earlier Windows operating systems.
This package will update Microsoft Security Essentials client on the user's machine.
security update for the .NET Framework 3.0.
This update resolves a vulnerability in the Microsoft .NET Framework that could allow denial of service if an attacker sends a few specially crafted requests to an affected .NET-enabled website.
I cannot see any similarity between these updates, except that they apparently
contain the same component which breaks your system.
Rather than trying to figure which component it is, I would try to do without them. In any case, you probably don't need numbers 2 and 4, and can do without
number 1 (at most you would need to manually correct the clock).
You could hide updates 1,2,4 to never see them again until new updates come out
to supersede them.
Number 3 is for Microsoft Security Essentials. You could maybe solve this by removing Microsoft Security Essentials, download the latest version and reinstall.
Otherwise, get another free antivirus - many of them are better than
Microsoft Security Essentials.
I don't think Microsoft makes any effort today as regarding Vista support.
Keeping Vista working and up to date might require some effort.