Probably not
There is a claim in fstrim(8) that
Running fstrim frequently, or even using mount -o discard, might negatively affect the lifetime of poor-quality SSD devices
The thing is, no good source corroborates it. Gentoo and LoginVSI are just making references to the single claim in the man page. Wikipedia claims that some drives do a copying GC cycle on TRIM, which would be a reasonable explanation, except that it also has no citation.
Is is possible? Yes, immature small manufacturers exist. Is it likely enough to concern you? Probably not, especially when your SSD controller is reasonably popular.
(Please post on the Internet if your SSD happens to be bad at TRIM. A possible test setup is SMART before and after readonly mount + fstrim. The problem is that you just don't get super fine-grained FTL write statistics on SMART except from Micron.)