Sorry for a late reply, but i have a fix for you. This covers your exact problem and any other programs that break after doing a Windows 10 "major OS update/upgrade".
Windows 10 Service packs/Upgrades (Anniversary, Creator, etc.,) are more or less OS Upgrades and they generate a Windows.old folder, move your Users and windows folder there, upgrade your OS and under normal circumstances are supposed to move back your Users folder and whatever it needs from the backed up Windows folder.
What happens is i believe your profile is in limbo or orphaned or something along those lines. Some of your data may actually be linked to the C:\windows.old\users folder as an example.
My fix: Create a new profile.
I had a home user bring her laptop in who could log into citrix until the recent upgrade came out last month. I made a new profile and citrix works correctly again. her documents and desktop were not moved back and were being linked to the C:\windows.old\users folder. My guess is her Appdata folder as well as her registry information was stored there also and while i'm sure there is a way to fix that, but creating a new profile was easier for me to do at the time.
Of course, you can also just back up your data and reload Windows 10 as well. If it happened to my computer, i would do that, because i wouldn't trust the OS at that point. However, creating a new profile is easier and if you have the time, you could probably research on why and how to fix the profile linking issue, if creating a new account/profile isn't an option.