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I know I can prevent a mouse from waking the system from sleep by unchecking "Allow this device to wake the computer". The problem is that if I plug the USB receiver of the wirelss mouse into a different USB port, that setting is lost. I have to uncheck it again.

Is there anyway to prevent the mouse from waking up the computer no matter which USB port the receiver is plugged into?

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You can use Powercfg.exe tool to disable a device from waking the computer from a sleep state.

Usage

powercfg -devicedisablewake devicename

devicename specifies a device retrieved by using the powercfg -devicequery wake_armed command.

Check the following link for detailed information about Powercfg.exe tool: Powercfg Command-Line Options

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    I also needed this to stop my USB wireless mouse from waking my machine. No amount of disabling the mouse wake in device manager would work. Feb 15, 2018 at 11:42
  • @MerseyViking I had the same problem as you describe and I finally found out that I had to disable my keyboard from waking the computer as well for it to work for the mouse. See answers.microsoft.com/en-us/windows/forum/windows_10-power/…. Jul 18, 2020 at 0:14

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