Some programs (e.g. ms html help viewer) have zoom-in features that only seem to work when you mouse wheel scroll.
Is there a way to emulate mouse wheel scroll using the keyboard?
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This is not a generic answer to your question, but notice that some softwares such as Visual Studio Code allow the documents to be scrolled using a key combination as well, so you might want to check out the configuration of the software you're using the most for such shortcut key settings. In my case, it's Ctrl + Up/Down in VSCode by default to scroll down as much as one line, and Alt + PageDown/PageUp to scroll down the whole page a few more lines(more than one line) down and up. I've personally remapped the latter to Alt + z/x since it's easier for my hand.
(Assuming Windows): Check out AutoHotKey, it can remap the Mouse Wheel.
From the docs:
Mouse Wheel Hotkeys [Windows NT/2000/XP or later]
Hotkeys that fire upon turning the mouse wheel are supported via the key names WheelDown and WheelUp. WheelLeft and WheelRight are also supported in v1.0.48+, but have no effect on operating systems older than Windows Vista.