Well... not directly, but very definitely indirectly.
There is a type of malware payload that builds the actual bytes of its executable using a code file that is already present on the target system. That pre-existing code file has to be exactly the same on each system that is to be infected. The only code in the supplied malware is the code that assembles the bytes, by knowing the position, byte for byte, of the code to be built.
For example, if the code file has the byte 0xF3 at position 105, and the next byte needed to assemble to malicious code is 0xF3, what is encoded with the building malware is "105", and it knows to get actual code byte from the file.
So, what file is the same on most/all Windows system, for example? It turns out, the Wingdings font file hasn't changed in Windows, going back as far as any modern-ish system is going to have.
And I didn't dream this up - it's all described here, with code examples..