I recently installed Windows XP Pro SP3 on an old PC. Everything seemed fine except for the fact that the 1 TB hard drive that I installed it to is called "H:" instead of "C:," like it usually is on Windows systems. The letter "C:" is instead assigned to a "Removable Disk Drive" (I believe one of the card readers that came with the desktop). Will re-installing XP with the card readers disconnected end up naming the HDD to "C:"? Also, will keeping "H:" as the main hard drive name present any possible problems with installing software (in other words, if I can fix it, is it really worth doing so)? Thanks.
Reinstalling may not fix the issue.
If the programs you use are written by competent programmers (which is mostly the case) drive letter of OS drive should not be a problem.
Here's a link that might you in renaming drive letter- https://www.computerhope.com/issues/ch000038.htm