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Windows Defender can no longer save settings. It's stuck at scanning all the time, the entire drive, and when the smallest file is downloaded. This is a slow-down in Visual Studio, Google Chrome etc. because it raises disk usage to 100% for 15-35 minutes after I hit 'close' on the application and it starts to scan every single file (In resource monitor appears that 24/7 it's scanning drivers, Chrome, Visual Studio folders). I tried to exclude these folders, what I get is this error message:

Windows Defender Error 0x80004002

How to fix this without a reinstall?

P.S.: Topics for "Explorer.exe No such interface supported" does not fix it.

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I solved this by installing Microsoft Security Essentials instead. https://support.microsoft.com/en-us/help/14210/security-essentials-download

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