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I try to save an Excel file with Ctrl+S, but that does not seem to work.

In particular, when I close the file, Excel asks: "Want to save your changes to ... ?" If I press "Don't Save", the changes made before pressing Ctrl+S are not saved.

If I press "Save" from the File menu, then Excel does not ask "Want to save your changes to ... ?", and the changes are indeed saved.

Ctrl+S is working in other applications. I am having this problem only with Excel.

Can one explain this behavior and teach me how to make Ctrl+S work with Excel?

Added: There seem to be no active add-ins:

enter image description here

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Ctrl-S works fine in Excel 2016 as well as in all previous versions of Excel.

Start Excel in Safe Mode to ensure there are no add-ins messing up your shortcut keys.

Does Ctrl-S now save the workbook?

If so, you have some software installed that overrides the Ctrl-S keyboard shortcut. Remove that software and Excel will respond correctly to Ctrl-S again.

Edit: To find the offending add-in, remove all add-ins. Then see if Ctrl-S works. Bring back one add-in at a time and test after each activation.

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  • Thank you very much for this hint. Indeed, Ctrl+S works in Safe Mode. Do you have any suggestions on how to find the offending application that overrides Ctrl+S for Excel, or maybe how to override that override? May 20, 2018 at 13:35
  • I added a suggestion to my answer.
    – teylyn
    May 20, 2018 at 21:46
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    Thank you for your further suggestion. Alas, there seem to have been no active Excel add-ins (see the snapshot added to my question), and yet Ctrl+S still is not working in the normal mode. Moreover, the changes saved by Ctrl+S in Safe Mode do not appear if I reopen the file in the normal mode. What is baffling and frustrating is that such unwelcome behavior appears to be only in Excel. May 21, 2018 at 1:11
  • In fact, the changes saved through the File menu in Safe Mode do not appear either if I reopen the file in the normal mode. May 21, 2018 at 1:16
  • These are Excel Add-ins. What about COM Add-ins?
    – teylyn
    May 21, 2018 at 7:50

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