I have been able to hide all the other 'This PC' folders (Documents, Downloads, Music, Pictures, Videos). Changing the actual directory path was easy. Hiding them from view in File Explorer was also not too hard. I followed this tutorial: http://www.thewindowsclub.com/remove-the-folders-from-this-pc-windows-10 and was able to hide them from view.
However, this has not worked for the Desktop directory. The actual path of the Desktop directory is not %USERPROFILE%, but some sort of link to it still appears in that directory when I'm using File Explorer.