I installed VirtualBox 5.2.22 from rpmfusion on a fresh install of Fedora 29. I installed Windows 10 Pro in a VM. Windows 10 seems to be running fine, but when I attempt to play any audio it's very choppy and broken. After some experimentation I realized that when I played an mp3 the time meter was running at about half speed. (i.e. it takes two seconds to play one second of audio) which explains the broken choppy sound.
I've done some googling, but haven't found any good answers. I found a couple of suggestions to use the ICH AC97 Audio Controller in VirtualBox, but I wasn't able to find drivers for it so I didn't get very far.
My host system is a Dell Precision 3510 with i7-6700HQ, 16Gb Ram and SSD. In VB I've given 4 CPUs and 4Gb Ram to the Windows 10 guest.