The other options did not directly work for me, however Luke Hsiao's tips [1] did.
With a Flatpack in Pop!_OS 20.04, I changed my ~/.local/share/flatpak/exports/share/applications/us.zoom.Zoom.desktop
to include QT_SCREEN_SCALE_FACTORS
env in the exec line.
First I ran xrandr
to find out my main screen is HDMI-A-0.
Then I prepended the env to the Exec line
Exec=env QT_SCREEN_SCALE_FACTORS=HDMI-A-0=2.00 /usr/bin/flatpak run --branch=stable --arch=x86_64 --command=zoom --file-forwarding us.zoom.Zoom @@u %U @@
If you have more monitors you can append their settings as comma-separated values.
[1] https://luke.hsiao.dev/blog/zoom-scaling/