In Windows, I always use 125% system DPI. Visual Studio ever since 2013, has not liked this. The typical font (Consolas) is rendered slightly "too short" vertically, it's essentially missing a row of pixels in the middle somewhere.
You can see it in this screenshot comparison, pay special attention to the letter "e":
There used to be a thread on Microsoft Connect forums about this, and there was a simple registry tweak that someone found, to fix it. Unfortunately, that site has since been dismantled, and the thread is gone. It used to be at this location: https://connect.microsoft.com/VisualStudio/feedback/details/800283/change-of-consolas-font-rendering-in-vs2013
There are other people too, who are still running into the issue today on every reinstall of Visual Studio, and they unfortunately want to look at that thread and see the registry tweak, but cannot: https://developercommunity.visualstudio.com/content/problem/67307/editor-font-is-squished-vertically-with-consolas-1.html and https://developercommunity.visualstudio.com/content/problem/2581/consolas-10-with-a-system-dpi-of-120-is-not-render.html
What is the registry tweak to fix this issue?