No advice given here can substitute to a visit to an optometrist.
You may discuss with him the points that are raised here, but remember that
we are not eye-specialists.
You may be sensitive to the back-light, the monitor may be too bright or maybe
uses too much blue tint that doesn't agree with your eyes.
You may check this by getting blue-light filters for your eyes
(if you don't wear glasses, there are special glasses that filter blue light,
or such filters can be added to the monitor screen, or Windows itself
could be set to filter blue light.)
Also, some monitors use PWM to adjust the brightness (the leds generating light are turned on and off tens of thousands of times a second), and it could happen that your eyes are particularly sensitive to a particular ratio of on and off switches. In this case, just reducing the brightness a bit may alter that ratio of on/off switching enough to reduce the strain on your eyes.
Whatever you try and whatever helps or not, should be concluded by a visit to the
optometrist.