I just got a new Asus laptop with Windows 10 Pro build 18363. I removed McAfee and Cortana, and disabled Cortana with a registry setting at Computer\HKEY_LOCAL_MACHINE\SOFTWARE\Policies\Microsoft\Windows\Windows Search
(Name AllowCortana, Value DWORD 1). Otherwise the Asus software seems okay. I might try to decrapify it a little further, but didn't want to go all-out yet.
Now when I do anything in Windows File Explorer, I get a one- to two-minute hang just left-clicking on folders. Explorer opens to "This PC", I double-click on C:\ and that opens immediately, but then I click on Program Files or any folder and I get the hourglass pointer while I wait over a minute, then the folder appears selected but I go right back to the hourglass pointer and a hang for over a minute, then the hourglass pointer goes back to an arrow and it works well again, except when I single-click on any folder, and I again get the hourglass pointer and a long hang. Can't switch tab or even move or resize the window.
The same hang happens when I single-click, double-click, or right click any folder or any quick link or "This PC" left-nav link. Clicking, opening, or right-clicking on actual files has no problem, but all folders seem to give the same issue.
I wondered if disabling Cortana could be related, so I removed the above mentioned registry value to allow Cortana, but that did not help.
What else can I do to troubleshoot this?
EDIT: I timed the delay and it always seems to be 85 seconds.
EDIT: When I browse folders inside an app's standard "Open" dialog, I can use it all without problems--whether in the main file view, Quick access, or This PC.