I have a Windows XP PC that's supposed to stay on without closing the screen etc. Even if the setting is set to
never, after a while the screen shuts down no matter what I chose.
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Use a third-party tool such as Caffeine, Don't Sleep or an alternative. They generally act by simulating a keypress or reporting a very important task that cannot be interrupted. Of course, check that the application is compatible with lab software.
You might also consider switching OS, if feasible, to one that's still supported. (A location where I worked kept Windows 3.1 running on one PC until well into Windows 8's reign, but finally chose to use new software!)